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Mathematical Biosciences and Engineering (MBE)
 

Effect of intraocular pressure on the hemodynamics of the central retinal artery: A mathematical model

Pages: 523 - 546, Volume 11, Issue 3, June 2014      doi:10.3934/mbe.2014.11.523

 
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Giovanna Guidoboni - Department of Mathematical Sciences, Indiana University - Purdue University at Indianapolis, Indianapolis, IN, United States (email)
Alon Harris - Department of Ophthalmology, Department of Cellular & Integrative Physiology, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, United States (email)
Lucia Carichino - Department of Mathematical Sciences, Indiana University - Purdue University at Indianapolis, Indianapolis, IN, United States (email)
Yoel Arieli - Department of Electro Optics, Jerusalem College of Technology, Jerusalem, Israel (email)
Brent A. Siesky - Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, United States (email)

Abstract: Retinal hemodynamics plays a crucial role in the pathophysiology of several ocular diseases. There are clear evidences that the hemodynamics of the central retinal artery (CRA) is strongly affected by the level of intraocular pressure (IOP), which is the pressure inside the eye globe. However, the mechanisms through which this occurs are still elusive. The main goal of this paper is to develop a mathematical model that combines the mechanical action of IOP and the blood flow in the CRA to elucidate the mechanisms through which IOP elevation affects the CRA hemodynamics. Our model suggests that the development of radial compressive regions in the lamina cribrosa (a collagen structure in the optic nerve pierced by the CRA approximately in its center) might be responsible for the clinically-observed blood velocity reduction in the CRA following IOP elevation. The predictions of the mathematical model are in very good agreement with experimental and clinical data. Our model also identifies radius and thickness of the lamina cribrosa as major factors affecting the IOP-CRA relationship, suggesting that anatomical differences among individuals might lead to different hemodynamic responses to IOP elevation.

Keywords:  Ocular blood flow, fluid-structure interaction, central retinal artery, intraocular pressure, lamina cribrosa.
Mathematics Subject Classification:  Primary: 76Z05, 74F10, 74L15; Secondary: 76Z05.

Received: May 2012;      Accepted: August 2013;      Available Online: January 2014.

 References