# American Institute of Mathematical Sciences

2015, 12(5): 983-1006. doi: 10.3934/mbe.2015.12.983

## Multi-host transmission dynamics of schistosomiasis and its optimal control

 1 Department of Applied Mathematics, Nanjing University of Science and Technology, Nanjing, 210094, China 2 LAboratory of Mathematical Parallel Systems (LAMPS), Centre for Disease Modeling, Department of Mathematics and Statistics, York University, Toronto, Ontario, M3J 1P3

Received  December 2014 Revised  March 2015 Published  June 2015

In this paper we formulate a dynamical model to study the transmission dynamics of schistosomiasis in humans and snails. We also incorporate bovines in the model to study their impact on transmission and controlling the spread of Schistosoma japonicum in humans in China. The dynamics of the model is rigorously analyzed by using the theory of dynamical systems. The theoretical results show that the disease free equilibrium is globally asymptotically stable if $\mathcal R_0<1$, and if $\mathcal R_0>1$ the system has only one positive equilibrium. The local stability of the unique positive equilibrium is investigated and sufficient conditions are also provided for the global stability of the positive equilibrium. The optimal control theory are further applied to the model to study the corresponding optimal control problem. Both analytical and numerical results suggest that: (a) the infected bovines play an important role in the spread of schistosomiasis among humans, and killing the infected bovines will be useful to prevent transmission of schistosomiasis among humans; (b) optimal control strategy performs better than the constant controls in reducing the prevalence of the infected human and the cost for implementing optimal control is much less than that for constant controls; and (c) improving the treatment rate of infected humans, the killing rate of the infected bovines and the fishing rate of snails in the early stage of spread of schistosomiasis are very helpful to contain the prevalence of infected human case as well as minimize the total cost.
Citation: Chunxiao Ding, Zhipeng Qiu, Huaiping Zhu. Multi-host transmission dynamics of schistosomiasis and its optimal control. Mathematical Biosciences & Engineering, 2015, 12 (5) : 983-1006. doi: 10.3934/mbe.2015.12.983
##### References:

show all references

##### References:
 [1] Kazeem Oare Okosun, Robert Smith?. Optimal control analysis of malaria-schistosomiasis co-infection dynamics. Mathematical Biosciences & Engineering, 2017, 14 (2) : 377-405. doi: 10.3934/mbe.2017024 [2] Linhua Zhou, Meng Fan, Qiang Hou, Zhen Jin, Xiangdong Sun. Transmission dynamics and optimal control of brucellosis in Inner Mongolia of China. Mathematical Biosciences & Engineering, 2018, 15 (2) : 543-567. doi: 10.3934/mbe.2018025 [3] Folashade B. Agusto. Optimal control and cost-effectiveness analysis of a three age-structured transmission dynamics of chikungunya virus. Discrete & Continuous Dynamical Systems - B, 2017, 22 (3) : 687-715. doi: 10.3934/dcdsb.2017034 [4] Arturo Alvarez-Arenas, Konstantin E. Starkov, Gabriel F. Calvo, Juan Belmonte-Beitia. Ultimate dynamics and optimal control of a multi-compartment model of tumor resistance to chemotherapy. Discrete & Continuous Dynamical Systems - B, 2019, 24 (5) : 2017-2038. doi: 10.3934/dcdsb.2019082 [5] Yingke Li, Zhidong Teng, Shigui Ruan, Mingtao Li, Xiaomei Feng. A mathematical model for the seasonal transmission of schistosomiasis in the lake and marshland regions of China. Mathematical Biosciences & Engineering, 2017, 14 (5&6) : 1279-1299. doi: 10.3934/mbe.2017066 [6] Chunhua Shan, Hongjun Gao, Huaiping Zhu. Dynamics of a delay Schistosomiasis model in snail infections. Mathematical Biosciences & Engineering, 2011, 8 (4) : 1099-1115. doi: 10.3934/mbe.2011.8.1099 [7] M'hamed Kesri. Structural stability of optimal control problems. Communications on Pure & Applied Analysis, 2005, 4 (4) : 743-756. doi: 10.3934/cpaa.2005.4.743 [8] Mingtao Li, Guiquan Sun, Juan Zhang, Zhen Jin, Xiangdong Sun, Youming Wang, Baoxu Huang, Yaohui Zheng. Transmission dynamics and control for a brucellosis model in Hinggan League of Inner Mongolia, China. Mathematical Biosciences & Engineering, 2014, 11 (5) : 1115-1137. doi: 10.3934/mbe.2014.11.1115 [9] Majid Jaberi-Douraki, Seyed M. Moghadas. Optimal control of vaccination dynamics during an influenza epidemic. Mathematical Biosciences & Engineering, 2014, 11 (5) : 1045-1063. doi: 10.3934/mbe.2014.11.1045 [10] Luca Galbusera, Sara Pasquali, Gianni Gilioli. Stability and optimal control for some classes of tritrophic systems. Mathematical Biosciences & Engineering, 2014, 11 (2) : 257-283. doi: 10.3934/mbe.2014.11.257 [11] Roberta Ghezzi, Benedetto Piccoli. Optimal control of a multi-level dynamic model for biofuel production. Mathematical Control & Related Fields, 2017, 7 (2) : 235-257. doi: 10.3934/mcrf.2017008 [12] Urszula Ledzewicz, Heinz Schättler, Mostafa Reisi Gahrooi, Siamak Mahmoudian Dehkordi. On the MTD paradigm and optimal control for multi-drug cancer chemotherapy. Mathematical Biosciences & Engineering, 2013, 10 (3) : 803-819. doi: 10.3934/mbe.2013.10.803 [13] Divya Thakur, Belinda Marchand. Hybrid optimal control for HIV multi-drug therapies: A finite set control transcription approach. Mathematical Biosciences & Engineering, 2012, 9 (4) : 899-914. doi: 10.3934/mbe.2012.9.899 [14] Paula A. González-Parra, Sunmi Lee, Leticia Velázquez, Carlos Castillo-Chavez. A note on the use of optimal control on a discrete time model of influenza dynamics. Mathematical Biosciences & Engineering, 2011, 8 (1) : 183-197. doi: 10.3934/mbe.2011.8.183 [15] Urszula Ledzewicz, Mohammad Naghnaeian, Heinz Schättler. Dynamics of tumor-immune interaction under treatment as an optimal control problem. Conference Publications, 2011, 2011 (Special) : 971-980. doi: 10.3934/proc.2011.2011.971 [16] Z.-R. He, M.-S. Wang, Z.-E. Ma. Optimal birth control problems for nonlinear age-structured population dynamics. Discrete & Continuous Dynamical Systems - B, 2004, 4 (3) : 589-594. doi: 10.3934/dcdsb.2004.4.589 [17] Yali Yang, Sanyi Tang, Xiaohong Ren, Huiwen Zhao, Chenping Guo. Global stability and optimal control for a tuberculosis model with vaccination and treatment. Discrete & Continuous Dynamical Systems - B, 2016, 21 (3) : 1009-1022. doi: 10.3934/dcdsb.2016.21.1009 [18] Sanjukta Hota, Folashade Agusto, Hem Raj Joshi, Suzanne Lenhart. Optimal control and stability analysis of an epidemic model with education campaign and treatment. Conference Publications, 2015, 2015 (special) : 621-634. doi: 10.3934/proc.2015.0621 [19] Alexander J. Zaslavski. Stability of a turnpike phenomenon for a class of optimal control systems in metric spaces. Numerical Algebra, Control & Optimization, 2011, 1 (2) : 245-260. doi: 10.3934/naco.2011.1.245 [20] Olha P. Kupenko, Rosanna Manzo. Shape stability of optimal control problems in coefficients for coupled system of Hammerstein type. Discrete & Continuous Dynamical Systems - B, 2015, 20 (9) : 2967-2992. doi: 10.3934/dcdsb.2015.20.2967

2018 Impact Factor: 1.313