# American Institute of Mathematical Sciences

July  2005, 13(4): 843-876. doi: 10.3934/dcds.2005.13.843

## Wave propagation and blocking in inhomogeneous media

 1 School of Mathematics, University of Minnesota, Minneappolis, MN 55455, United States, United States 2 School of Mathematics, 270A Vincent Hall, University of Minnesota, Minneapolis, MN 55455, United States

Received  November 2004 Revised  April 2005 Published  August 2005

Wave propagation governed by reaction-diffusion equations in homogeneous media has been studied extensively, and initiation and propagation are well understood in scalar equations such as Fisher's equation and the bistable equation. However, in many biological applications the medium is inhomogeneous, and in one space dimension a typical model is a series of cells, within each of which the dynamics obey a reaction-diffusion equation, and which are coupled by reaction-free gap junctions. If the cell and gap sizes scale correctly such systems can be homogenized and the lowest order equation is the equation for a homogeneous medium [11]. However this usually cannot be done, as evidenced by the fact that such averaged equations cannot predict a finite range of propagation in an excitable system; once a wave is fully developed it propagates indefinitely. However, recent experimental results on calcium waves in numerous systems show that waves propagate though a fixed number of cells and then stop. In this paper we show how this can be understood within the framework of a very simple model for excitable systems.
Citation: D. G. Aronson, N. V. Mantzaris, Hans Othmer. Wave propagation and blocking in inhomogeneous media. Discrete & Continuous Dynamical Systems - A, 2005, 13 (4) : 843-876. doi: 10.3934/dcds.2005.13.843
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