Approximate marginalization of unknown scattering in quantitative photoacoustic tomography
Aki Pulkkinen Ville Kolehmainen Jari P. Kaipio Benjamin T. Cox Simon R. Arridge Tanja Tarvainen
Inverse Problems & Imaging 2014, 8(3): 811-829 doi: 10.3934/ipi.2014.8.811
Quantitative photoacoustic tomography is a hybrid imaging method, combining near-infrared optical and ultrasonic imaging. One of the interests of the method is the reconstruction of the optical absorption coefficient within the target. The measurement depends also on the uninteresting but often unknown optical scattering coefficient. In this work, we apply the approximation error method for handling uncertainty related to the unknown scattering and reconstruct the absorption only. This way the number of unknown parameters can be reduced in the inverse problem in comparison to the case of estimating all the unknown parameters. The approximation error approach is evaluated with data simulated using the diffusion approximation and Monte Carlo method. Estimates are inspected in four two-dimensional cases with biologically relevant parameter values. Estimates obtained with the approximation error approach are compared to estimates where both the absorption and scattering coefficient are reconstructed, as well to estimates where the absorption is reconstructed, but the scattering is assumed (incorrect) fixed value. The approximation error approach is found to give better estimates for absorption in comparison to estimates with the conventional measurement error model using fixed scattering. When the true scattering contains stronger variations, improvement of the approximation error method over fixed scattering assumption is more significant.
keywords: quantitative photoacoustic tomography uncertainty quantification numerical methods. approximation error parameter estimation Inverse problems
Approximate marginalization of absorption and scattering in fluorescence diffuse optical tomography
Meghdoot Mozumder Tanja Tarvainen Simon Arridge Jari P. Kaipio Cosimo D'Andrea Ville Kolehmainen
Inverse Problems & Imaging 2016, 10(1): 227-246 doi: 10.3934/ipi.2016.10.227
In fluorescence diffuse optical tomography (fDOT), the reconstruction of the fluorophore concentration inside the target body is usually carried out using a normalized Born approximation model where the measured fluorescent emission data is scaled by measured excitation data. One of the benefits of the model is that it can tolerate inaccuracy in the absorption and scattering distributions that are used in the construction of the forward model to some extent. In this paper, we employ the recently proposed Bayesian approximation error approach to fDOT for compensating for the modeling errors caused by the inaccurately known optical properties of the target in combination with the normalized Born approximation model. The approach is evaluated using a simulated test case with different amount of error in the optical properties. The results show that the Bayesian approximation error approach improves the tolerance of fDOT imaging against modeling errors caused by inaccurately known absorption and scattering of the target.
keywords: Bayesian methods inverse problems tomography fluorescence diffuse optical tomography. Image reconstruction techniques
Nonstationary inversion of convection-diffusion problems - recovery from unknown nonstationary velocity fields
Antti Lipponen Aku Seppänen Jari Hämäläinen Jari P. Kaipio
Inverse Problems & Imaging 2010, 4(3): 463-483 doi: 10.3934/ipi.2010.4.463
In this paper, we consider the reconstruction of time-varying concentration distributions under nonstationary flow conditions. Previous studies have shown that the state estimation approach that is based on stochastic process evolution models, facilitates reconstructions of rapidly time-varying targets. However, only cases with stationary velocity fields, or cases in which the velocity field can be completely specified by a velocity profile, have been studied. While simultaneous estimation of the time-varying concentration and low-dimensional representations of the flow field itself has been shown to be possible to some extent, this would be computationally too heavy for on-line process estimation and control. On the other hand, using an incorrect flow model in the evolution model may induce intolerable estimation errors. In this paper, we consider an approach in which the state evolution model is written to correspond to a stationary flow, while the actual flow is nonstationary. The associated modelling errors are handled by constructing the state noise process to accommodate to this discrepancy. We carry out a numerical feasibility study with different Reynolds numbers and show that the approach yields significant reduction of estimation errors and simultaneously facilitates using computationally efficient reduced order models.
keywords: state estimation approximation errors. nonstationary inversion convection-diffusion problems
Model reduction and pollution source identification from remote sensing data
A Voutilainen Jari P. Kaipio
Inverse Problems & Imaging 2009, 3(4): 711-730 doi: 10.3934/ipi.2009.3.711
We consider a source identification problem related to determination of contaminant source parameters in lake environments using remote sensing measurements. We carry out a numerical example case study in which we employ the statistical inversion approach for the determination of the source parameters. In the simulation study a pipeline breaks on the bottom of a lake and only low-resolution remote sensing measurements are available. We also describe how model uncertainties and especially errors that are related to model reduction are taken into account in the overall statistical model of the system. The results indicate that the estimates may be heavily misleading if the statistics of the model errors are not taken into account.
keywords: approximation error Bayesian inference. model reduction inverse problem Source identification
Adaptive meshing approach to identification of cracks with electrical impedance tomography
Kimmo Karhunen Aku Seppänen Jari P. Kaipio
Inverse Problems & Imaging 2014, 8(1): 127-148 doi: 10.3934/ipi.2014.8.127
Electrical impedance tomography (EIT) is a non-invasive imaging modality in which the internal conductivity distribution is reconstructed based on boundary voltage measurements. In this work, we consider the application of EIT to non-destructive testing (NDT) of materials and, especially, crack detection. The main goal is to estimate the location, depth and orientation of a crack in three dimensions. We formulate the crack detection task as a shape estimation problem for boundaries imposed with Neumann zero boundary conditions. We propose an adaptive meshing algorithm that iteratively seeks the maximum a posteriori estimate for the shape of the crack. The approach is tested both numerically and experimentally. In all test cases, the EIT measurements are collected using a set of electrodes attached on only a single planar surface of the target -- this is often the only realizable configuration in NDT of large building structures, such as concrete walls. The results show that with the proposed computational method, it is possible to recover the position and size of the crack, even in cases where the background conductivity is inhomogeneous.
keywords: crack identification Electrical impedance tomography non-destructive testing.

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