DCDS-S
Experimental data for solid tumor cells: Proliferation curves and time-changes of heat shock proteins
Kazuhiko Yamamoto Kiyoshi Hosono Hiroko Nakayama Akio Ito Yuichi Yanagi
We consider a relation between proliferation of solid tumor cells and time-changes of the quantities of heat shock proteins in them. To do so, in the present paper we start to obtain some experimental data of the proliferation curves of solid tumor cells, actually, A549 and HepG2, as well as the time-changes of proteins, especially HSP90 and HSP72, in them. And we propose a mathematical model to re-create the experimental data of the proliferation curves and the time-changes of the quantities of heat shock proteins, which is described by ODE systems. Finally, we discuss a problem which exists between mitosis of solid tumor cells and time-changes of the quantities of heat shock proteins, from the viewpoint of biotechnology.
keywords: Time-change of HSP. Experimental data Proliferation curve

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