Mathematical Biosciences and Engineering (MBE)

Germinal center dynamics during acute and chronic infection
Pages: 655 - 671, Issue 3, June 2017

doi:10.3934/mbe.2017037      Abstract        References        Full text (1257.9K)           Related Articles

Samantha Erwin - 460 McBryde Hall, Virginia Tech, Blacksburg, VA 24061, United States (email)
Stanca M. Ciupe - 460 McBryde Hall, Virginia Tech, Blacksburg, VA 24061, United States (email)

1 C. Allen, T. Okada and J. Cyster, Germinal-center organization and cellular dynamcs, Immunity, 27 (2007), 190-202.
2 B. Asquith, C. Debacq, A. Florins, N. Gillet, T. Sanchez-Alcaraz, A. Mosley and L. Willems, Quantifying lymphocyte kinetics in vivo using carboxyfluorescein diacetate succinimidyl ester (CFSE), Proc Biol Sci, 273 (2006), 1165-1171.
3 D. Burton and J. Mascola, Antibody responses to envelope glycoproteins in HIV-1 infection, Nat Immunol, 16 (2015), 571-576.
4 R. Cubas, J. Mudd, A. Savoye, M. Perreau, J. van Grevenynghe and et al, Inadequate T follicular cell help impairs B cell immunity during HIV infection, Nat Med, 19 (2013), 494-499.
5 R. De Boer and A. Perelson, Quantifying T lymphocyte turnover, J Theor Biol, 327 (2013), 45-87.       
6 A. Hauser, M. Shlomchik and A. Haberman, In vivo imaging studies shed light on germinal-centre development, Nat Rev Immunol, 7 (2007), 499-504.
7 B. Haynes, New approaches to HIV vaccine development, Curr Opin Immunol, 35 (2015), 39-47.
8 P. Hodgkin, J. Lee and A. Lyons, B cell differentiation and isotype switching is related to division cycle number, J Exp Med, 184 (1996), 277-281.
9 K. Hollowood and J. Macartney, Cell kinetics of the germinal center reaction - a stathmokinetic study, Eur J Immunol, 22 (1992), 261-266.
10 T. Kepler and A. Perelson, Cyclic re-entry of germinal center B cells and the efficiency of affinity maturations, Immunol Today, 14 (1993), 412-415.
11 C. Kesmir and R. De Boer, A mathematical model on germinal center kinetics and termination, J Immunol, 163 (1999), 2463-2469.
12 C. Kesmir and R. de Boer, A spatial model of germinal center reactions: Cellular adhesion based sorting of B cells results in efficient affinity maturation, J Theor Biol, 222 (2003), 9-22.       
13 F. Kroese, A. Wubbena, H. Seijen and P. Nieuwenhuis, Germinal centers develop oligoclonally, Eur J Immunol, 17 (1987), 1069-1072.
14 R. Kuppers, M. Zhao, M. Hansmann and K. Rajewsky, Tracing B cell development in human germinal centers by molecular analysis of single cells picked from histological sections, Embo J, 12 (1993), 4955-4967.
15 P. Kwong and J. Mascola, Human antibodies that neutralize HIV-1: Identification, structures, and B cell ontogenies, Immunity, 37 (2012), 412-425.
16 V. L and M. Diaz, Autoreactivity in HIV-1 broadly neutralizing antibodies: Implications for their function and induction by vaccination, Curr Opin HIV AIDS, 9 (2014), 224-234.
17 H. Lee, E. Hawkins, M. Zand, T. Mosmann, H. Wu and et al., Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models, Bull Math Biol, 71 (2009), 1649-1670.       
18 M. Lindqvist, J. van Lunzen, D. Soghoian, B. Kuhl, S. Ranasinghe and et all, Expansion of HIV-specific T follicular helper cells in chronic HIV infection, J Clin Invest, 122 (2012), 3271-3280.
19 I. MacLennan, Germinal centers, Annu Rev Immunol., 12 (1994), 117-139.
20 M. Meyer-Hermann, E. Mohr, N. Pelletier, Y. Zhang, G. Victoria and K. Toellner, A theory of germinal center B cell selection, division, and exit, Cell Reports, 2 (2012), 162-174.
21 M. Meyer-Hermann, M. Figge and K. Toellner, Germinal centres seen through the mathematical eye: B-cell models on the catwalk, Trends in Immunol, 30 (2009), 157-164.
22 M. Meyer-Hermann and P. Maini, Cutting edge: Back to one-way germinal centers, J Immunol, 174 (2005), 2489-2493.
23 M. Meyer-Hermann, P. Maini and D. Iber, An analysis of B cell selection mechanisms in germinal centers, Math Med Biol, 23 (2006), 255-277.
24 H. Miao, X. Jin, A. Perelson and H. Wu, Evaluation of multitype mathematical models for CFSE-labeling experiment data, Bull Math Biol, 74 (2012), 300-326.       
25 I. Mikell, D. Sather, S. Kalams, M. Altfeld, G. Alter and L. Stamatatos, Characteristics of the earliest cross-neutralizing antibody response to HIV-1, PLoS Pathog, 7 (2011), 1-15.
26 M. Moody, R. Zhang, E. Walter, C. Woods, G. Ginsburg and et al., H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination, PLoS One, 6 (2011), e25797, 14pp.
27 J. Moreira and J. Faro, Modelling two possible mechanisms for the regulation of the germinal center dynamics, J Immunol, 177 (2006), 3705-3710.
28 M. Oprea and A. Perelson, Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts, J Immunol, 158 (1997), 5155-5162.
29 M. Oprea, E. van Nimwegen and A. Perelson, Dynamics of one-pass germinal center models: Implications for affinity maturation, Bull Math Biol, 62 (2000), 121-153.
30 S. Pallikkuth, A. Parmigiani and S. Pahwa, The role of interleukin-21 in HIV infection, Cytokine growth factor rev, 23 (2012), 173-180.
31 M. Perreau, A.-L. Savoye, E. De Crignis, J. Corpataux, R. Cubas and et al, Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production, J Exp Med, 210 (2013), 143-156.
32 J. Publicover, A. Gaggar, S. Nishimura, C. Van Horn, A. Goodsell and et al, Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B, J Clin Invest, 123 (2013), 3728-3739.
33 J. Publicover, A. Goodsell, S. Nishimura, S. Vilarinho, Z. Wang and et al., IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B, J Clin Invest, 121 (2011), 1154-1162.
34 M. Radmacher, G. Kelsoe and T. Kepler, Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection, Immunol and Cell Bio, 76 (1998), 373-381.
35 T. Schwickert, G. Victoria, D. Fooksman, A. Kamphorst, M. Mugnier and et al, A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center, J Exp Med, 208 (2011), 1243-1252.
36 Z. Shulman, A. Gitlin, S. Targ, M. Jankovic, G. Pasqual and et al., T follicular helper cell dynamics in germinal centers, Science, 341 (2013), 673-677.
37 G. Siskind and B. Benacerraf, Cell selection by antigen in the immune response, Adv. Immunol., 10 (1969), 1-50.
38 M. Stafford, L. Corey, Y. Cao, E. Daar, D. Ho and A. Perelson, Modeling plasma virus concentration during primary HIV infection, J theor Biol, 203 (2000), 285-301.
39 L. Stamatatos, HIV vaccine design: The neutralizing antibody conundrum, Curr Opin Immunol, 24 (2012), 316-323.
40 L. Stamatatos, L. Morris, D. Burton and J. Mascola, Neutralizing antibodies generated during natural HIV-1 infection: Good news for an HIV-1 vaccine?, Nat Med, 15 (2009), 866-870.
41 L. Verkoczy, G. Kelsoe, M. Moody and B. Haynes, Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies, Curr Opin Immunol, 23 (2011), 383-390.
42 G. Victora and L. Mesin, Clonal and cellular dynamics in germinal centers, Curr Opin Immunol, 28 (2014), 90-96.
43 C. Vinuesa, HIV and T follicular helper cells: A dangerous relationship, J Clin Invest, 122 (2012), 3059-3062.
44 C. Vinuesa, I. Sanz and M. Cook, Dysregulation of germinal centres in autoimmune disease, Nat Rev Immunol, 9 (2009), 845-857.
45 J. Weinstein, S. Hernandez and J. Craft, T cells that promote B-cell maturation in systemic autoimmunity, Immunol Rev, 247 (2012), 160-171.
46 I. Wollenberg, A. Agua-Doce, A. Hernandez, C. Almeida, V. Oliveira and et al., Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells, J Immunol, 187 (2011), 4553-4560.
47 X. Wu, T. Zhou, J. Zhu, B. Zhang, I. Georgiev and et al., Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing, Science, 333 (2011), 1593-1602.
48 X. Zhang, S. Ing, A. Fraser, M. Chen, O. Khan, J. Zakem and et al., Follicular helper T cells: New insights into mechanisms of autoimmune diseases, Ochsner J, 13 (2013), 131-139.

Go to top