doi: 10.3934/jimo.2018079

Predicting 72-hour reattendance in emergency departments using discriminant analysis via mixed integer programming with electronic medical records

1. 

Department of Health Services and Outcomes Research, National Healthcare Group, 138543, Singapore

2. 

Department of Emergency Medicine, Tan Tock Seng Hospital, 308433, Singapore

* Corresponding author

Received  October 2017 Revised  January 2018 Published  June 2018

The proportion of patients who reattended emergency department (ED) within 72 hours is an important indicator of quality of care. This study develops a practical framework to predict patients who will reattend ED in 72 hours from clinical perspectives. We analyze 328,733 ED patients from 1 January 2011 to 31 December 2013, with an average of 4.6% reattendances. We feature over 100 factors including demographics, diagnosis, patient acuity, chief complaints, selected laboratory tests, summarized vital signs. Using univariate analysis, a pool of risk variables is selected for subsequent factor selection. We then apply filter methods to derive a set of candidate factors. With these factors in combination with suggestions from ED clinicians, a mixed integer programming model based on discriminant analysis is proposed to determine a classification rule for 72-hour reattendance. In numerical experiments, various small subsets of risk factors are used for classification and prediction. The results show that favorable predicting performances can be achieved in both training and test sets.

Citation: Fanwen Meng, Kiok Liang Teow, Kelvin Wee Sheng Teo, Chee Kheong Ooi, Seow Yian Tay. Predicting 72-hour reattendance in emergency departments using discriminant analysis via mixed integer programming with electronic medical records. Journal of Industrial & Management Optimization, doi: 10.3934/jimo.2018079
References:
[1]

E. A. AlessandriniJ. M. LavelleS. M. GrenfellC. R. Jacobstein and K. N. Shaw, Return visits to a pediatric emergency department, Pediatr. Emerg. Care, 20 (2004), 166-171.

[2]

J. A. Anderson, Constrained discrimination between k populations, J. R. Stat. Soc. Series B, 31 (1969), 123-139.

[3]

D. AujeskyM. K. MorM. GengR. A. StoneM. J. Fine and S. A. Ibrahim, Predictors of early hospital readmission after acute pulmonary embolism, Arch. Intern. Med., 169 (2009), 287-293. doi: 10.1001/archinternmed.2008.546.

[4]

K. P. Bennett and O. L. Mangasarian, Robust linear programming discrimination of two linearly inseparable sets, Optim. Method Softw., 1 (1992), 23-34. doi: 10.1080/10556789208805504.

[5]

R. T. Boonyasai, O. M. Ijagbemi and J. C. Pham et al, Improving the Emergency Department Discharge Process, Agency for Healthcare Research and Quality, Rockville, Maryland, United States. 2014.

[6]

G. BrownA. PocockM.-J. Zhao and M. Luján, Conditional likelihood maximisation: A unifying framework for information theoretic feature selection, J. Mach. Learn. Res., 13 (2012), 27-66.

[7]

CDC, ICD-9-CM official guidelines for coding and reporting, http://www.cdc.gov/nchs/data/icd/icd9cm$_{-}$guidelines$_{-}$2011.pdf (accessed on 20 March 2016).

[8]

R. J. GallagherE. K. Lee and D. A. Patterson, Constrained discriminant analysis via 0/1 mixed integer programming, Ann. Oper. Res., 74 (1997), 65-88.

[9]

E. GoksuC. OktayM. KartalA. Oskay and A. V. Sayrac, Factors affecting revisit of COPD exacerbated patients presenting to emergency department, Eur. J. Emerg. Med., 17 (2010), 283-285. doi: 10.1097/MEJ.0b013e3283314795.

[10]

C. Y. Han, L. C. Chen, A. Barnard, C. C. Lin, Y. C. Hsiao and H. E. Liu et al, Early revisit to the emergency department: An integrative review, J. Emerg. Nurs., 41 (2015), 285-295 doi: 10.1016/j.jen.2014.11.013.

[11]

S. Hao, B. Jin and A. Y. Shin et al, Risk prediction of emergency department revisit 30 days post discharge: A prospective study, PLoS One, 10 (2015), e0117633. doi: 10.1371/journal.pone.0112944.

[12]

S. C. Hu, Analysis of patient revisits to the emergency department, Am. J. Emerg. Med., 10 (1992), 366-370.

[13]

I. Imsuwan, Characteristics of unscheduled emergency department return visit patients within 48 hours in Thammasat university hospital, J. Med. Assoc. Thai., 94 (2011), S73-S80.

[14]

Y. JenabS. HaghaniA. Jalali and F. Darabi, Unscheduled return visits and leaving the chest pain unit against medical advice, Iran Red Crescent Med. J., 17 (2015), e18320. doi: 10.5812/ircmj.17(5)2015.18320.

[15]

K. D. KeithJ. J. BockaM. S. KobernickR. L. Krome and M. A. Ross, Emergency department revisits, Ann. Emerg. Med., 18 (1989), 964-968. doi: 10.1016/S0196-0644(89)80461-5.

[16]

M. KoY. LeeC. ChenP. Chou and D. Chu, Incidence of and predictors for early return visits to the emergency department: a population-based survey, Medicine, 94 (2015), e1770. doi: 10.1097/MD.0000000000001770.

[17]

E. K. Lee, Y. Wang, M. S. Hagen, X. Wei, R. A. Davis and B. M. Egan, Machine learning: Multi-site evidence-based best practice discovery, in Machine Learning, Optimization, and Big Data. MOD 2016. Lecture Notes in Computer Science (eds. P. Pardalos, P. Conca, G. Giuffrida and G. Nicosia), Springer, Cham, (2016), 1-15. doi: 10.1007/978-3-319-51469-7_1.

[18]

E. K. Lee, Large-scale optimization-based classification models in medicine and biology, Ann. Biomed. Eng., 35 (2007), 1095-1109. doi: 10.1007/s10439-007-9317-7.

[19]

E. K. LeeF. YuanD. HirshM. Mallory and H. K. Simon, A clinical decision tool for predicting patient care characteristics: patients returning within 72 hours in the emergency department, AMIA Annu. Symp. Proc., (2012), 495-504.

[20]

E. K. LeeR. J. Gallagher and D. A. patterson, A linear programming approach to discriminant analysis with a reserved-judgment region, INFORMS J. Comput., 15 (2003), 23-41. doi: 10.1287/ijoc.15.1.23.15158.

[21]

S. J. LiawM. J. BullardP. M. HuJ. C. Chen and H. C. Liao, Rates and causes of emergency department revisits within 72 hours, J. Formos Med. Assoc., 98 (1999), 422-425.

[22]

J. A. LowthianA. J. Curtis and P. A. Cameron et al, Systematic review of trends in emergency department attendances: an Australian perspective, Emerg. Med. J., 28 (2011), 373-377. doi: 10.1136/emj.2010.099226.

[23]

F. MengC. K. OoiC. K. K. SohK. L. Teow and P. Kannapiran, Quantifying patient flow and utilization with patient flow pathway and diagnosis of an emergency in Singapore, Health Syst., 5 (2016), 140-148. doi: 10.1057/hs.2015.15.

[24]

F. MengJ. QiM. ZhangJ. AngS. Chu and M. Siim, A robust optimization model for managing elective admission in a public hospital, Oper. Res., 63 (2015), 1452-1467. doi: 10.1287/opre.2015.1423.

[25]

A. S. NewtonS. AliD. W. JohnsonC. HainesR. J. RosychukR. A. KeaschukP. JacobsM. Cappelli and T. P. Klassen, Who comes back? Characteristics and predictors of return to emergency department services for pediatric mental health care, Acad. Emerg. Med., 17 (2010), 177-186. doi: 10.1111/j.1553-2712.2009.00633.x.

[26]

Y. Y. Ng, Optimal use of emegency services, SFP, 40 (2014), supplement 8-13.

[27]

S. NunëzA. Hexdall and A. Aguirre-Jaime, Unscheduled returns to the emergency department: An outcome of medical errors?, Qual. Saf. Health Care., 15 (2006), 102-108.

[28]

K. O'LoughlinK. A. HackingN. SimmonsW. ChristianR. SyahaneeA. Shamekh and N. J. Prince, Paediatric unplanned reattendance rate: A&E clinical quality indicators, Arch. Dis. Child., 98 (2013), 211-213.

[29]

L. Pereira, C. Choquet and A. Perozziello et al, Unscheduled return visits after an emergency department (ED) attendance and clinical link between both visits in patients aged 75 years and over: a prospective observational study, PloS One, 10 (2015), e0123803. doi: 10.1371/journal.pone.0123803.

[30]

H. QiuX. ChenW. LiuG. ZhouY. Wang and J. Lai, A fast11-solver and its applications to robust face recognition, J. Ind. Manag. Optim., 8 (2012), 163-178.

[31]

J. RyanJ. Hendler and K. P. Bennett, Understanding emergency department 72-hour revisits among medicaid patients using electronic healthcare records, Big Data, 3 (2015), 238-248. doi: 10.1089/big.2015.0038.

[32]

Y. Saeys, I. Inza and P. Larrañaga, A review of feature selection techniques in bioinformatics, 23 (2007), 2507-2517. doi: 10.1093/bioinformatics/btm344.

[33]

G. SauvinY. FreundK. SaidiB. Riou and P. Hausfater, Unscheduled return visits to the emergency department: Consequences for triage, Acad. Emerg. Med., 20 (2013), 33-39. doi: 10.1111/acem.12052.

[34]

Y. SunB. H. HengS. Y. Tay and K. B. Tan, Unplanned 3-day re-attendance rate at Emergency Department and hospital's bed occupancy rate, Int. J. Emerg. Med., 8 (2015), 324-329. doi: 10.1186/s12245-015-0082-3.

[35]

C. R. Trivedy and M. W. Cooke, Unscheduled-return-visits (URV) in adults to the emergency department (ED): A rapid evidence assessment policy review, Emerg. Med. J., 32 (2015), 324-329. doi: 10.1136/emermed-2013-202719.

[36]

S. J. J. VerelstS. PierlootD. DesruellesJ.-B. Gillet and J. Bergs, Short-term unscheduled return visits of adult patients to the emergency department, J. Emerg. Med., 47 (2014), 131-199. doi: 10.1016/j.jemermed.2014.01.016.

[37]

A. K. C. WaiC. M. ChorA. T. C. LeeY. SittambunkaC. A. Graham and T. H. Rainer, Analysis of trends in emergency department attendances, hospital admissions and medical staffing in a Hong Kong university hospital: 5-year study, Int J. Emerg. Med., 2 (2009), 141-148. doi: 10.1007/s12245-009-0098-7.

[38]

Y. WangG. ZhouL. Caccetta and W. Liu, An alternative Lagrange-dual based algorithm for sparse signal reconstruction, IEEE Trans. Sig. Process., 59 (2011), 1895-1901. doi: 10.1109/TSP.2010.2103066.

[39]

C. Wei and X. Tang, A fuzzy group decision making approach based on entropy, similarity measure, Int. J. Inf. Technol. Decis. Mak., 10 (2011), 1111-1130. doi: 10.1142/S0219622011004737.

[40]

C. L. WuF. T. WangY. C. ChiangY. F. ChiuT. G. Lin and L. F. Fu et al, Unplanned emergency department revisits within 72 hours to a secondary teaching referral hospital in Taiwan, J. Emerg. Med., 38 (2010), 512-517. doi: 10.1016/j.jemermed.2008.03.039.

show all references

References:
[1]

E. A. AlessandriniJ. M. LavelleS. M. GrenfellC. R. Jacobstein and K. N. Shaw, Return visits to a pediatric emergency department, Pediatr. Emerg. Care, 20 (2004), 166-171.

[2]

J. A. Anderson, Constrained discrimination between k populations, J. R. Stat. Soc. Series B, 31 (1969), 123-139.

[3]

D. AujeskyM. K. MorM. GengR. A. StoneM. J. Fine and S. A. Ibrahim, Predictors of early hospital readmission after acute pulmonary embolism, Arch. Intern. Med., 169 (2009), 287-293. doi: 10.1001/archinternmed.2008.546.

[4]

K. P. Bennett and O. L. Mangasarian, Robust linear programming discrimination of two linearly inseparable sets, Optim. Method Softw., 1 (1992), 23-34. doi: 10.1080/10556789208805504.

[5]

R. T. Boonyasai, O. M. Ijagbemi and J. C. Pham et al, Improving the Emergency Department Discharge Process, Agency for Healthcare Research and Quality, Rockville, Maryland, United States. 2014.

[6]

G. BrownA. PocockM.-J. Zhao and M. Luján, Conditional likelihood maximisation: A unifying framework for information theoretic feature selection, J. Mach. Learn. Res., 13 (2012), 27-66.

[7]

CDC, ICD-9-CM official guidelines for coding and reporting, http://www.cdc.gov/nchs/data/icd/icd9cm$_{-}$guidelines$_{-}$2011.pdf (accessed on 20 March 2016).

[8]

R. J. GallagherE. K. Lee and D. A. Patterson, Constrained discriminant analysis via 0/1 mixed integer programming, Ann. Oper. Res., 74 (1997), 65-88.

[9]

E. GoksuC. OktayM. KartalA. Oskay and A. V. Sayrac, Factors affecting revisit of COPD exacerbated patients presenting to emergency department, Eur. J. Emerg. Med., 17 (2010), 283-285. doi: 10.1097/MEJ.0b013e3283314795.

[10]

C. Y. Han, L. C. Chen, A. Barnard, C. C. Lin, Y. C. Hsiao and H. E. Liu et al, Early revisit to the emergency department: An integrative review, J. Emerg. Nurs., 41 (2015), 285-295 doi: 10.1016/j.jen.2014.11.013.

[11]

S. Hao, B. Jin and A. Y. Shin et al, Risk prediction of emergency department revisit 30 days post discharge: A prospective study, PLoS One, 10 (2015), e0117633. doi: 10.1371/journal.pone.0112944.

[12]

S. C. Hu, Analysis of patient revisits to the emergency department, Am. J. Emerg. Med., 10 (1992), 366-370.

[13]

I. Imsuwan, Characteristics of unscheduled emergency department return visit patients within 48 hours in Thammasat university hospital, J. Med. Assoc. Thai., 94 (2011), S73-S80.

[14]

Y. JenabS. HaghaniA. Jalali and F. Darabi, Unscheduled return visits and leaving the chest pain unit against medical advice, Iran Red Crescent Med. J., 17 (2015), e18320. doi: 10.5812/ircmj.17(5)2015.18320.

[15]

K. D. KeithJ. J. BockaM. S. KobernickR. L. Krome and M. A. Ross, Emergency department revisits, Ann. Emerg. Med., 18 (1989), 964-968. doi: 10.1016/S0196-0644(89)80461-5.

[16]

M. KoY. LeeC. ChenP. Chou and D. Chu, Incidence of and predictors for early return visits to the emergency department: a population-based survey, Medicine, 94 (2015), e1770. doi: 10.1097/MD.0000000000001770.

[17]

E. K. Lee, Y. Wang, M. S. Hagen, X. Wei, R. A. Davis and B. M. Egan, Machine learning: Multi-site evidence-based best practice discovery, in Machine Learning, Optimization, and Big Data. MOD 2016. Lecture Notes in Computer Science (eds. P. Pardalos, P. Conca, G. Giuffrida and G. Nicosia), Springer, Cham, (2016), 1-15. doi: 10.1007/978-3-319-51469-7_1.

[18]

E. K. Lee, Large-scale optimization-based classification models in medicine and biology, Ann. Biomed. Eng., 35 (2007), 1095-1109. doi: 10.1007/s10439-007-9317-7.

[19]

E. K. LeeF. YuanD. HirshM. Mallory and H. K. Simon, A clinical decision tool for predicting patient care characteristics: patients returning within 72 hours in the emergency department, AMIA Annu. Symp. Proc., (2012), 495-504.

[20]

E. K. LeeR. J. Gallagher and D. A. patterson, A linear programming approach to discriminant analysis with a reserved-judgment region, INFORMS J. Comput., 15 (2003), 23-41. doi: 10.1287/ijoc.15.1.23.15158.

[21]

S. J. LiawM. J. BullardP. M. HuJ. C. Chen and H. C. Liao, Rates and causes of emergency department revisits within 72 hours, J. Formos Med. Assoc., 98 (1999), 422-425.

[22]

J. A. LowthianA. J. Curtis and P. A. Cameron et al, Systematic review of trends in emergency department attendances: an Australian perspective, Emerg. Med. J., 28 (2011), 373-377. doi: 10.1136/emj.2010.099226.

[23]

F. MengC. K. OoiC. K. K. SohK. L. Teow and P. Kannapiran, Quantifying patient flow and utilization with patient flow pathway and diagnosis of an emergency in Singapore, Health Syst., 5 (2016), 140-148. doi: 10.1057/hs.2015.15.

[24]

F. MengJ. QiM. ZhangJ. AngS. Chu and M. Siim, A robust optimization model for managing elective admission in a public hospital, Oper. Res., 63 (2015), 1452-1467. doi: 10.1287/opre.2015.1423.

[25]

A. S. NewtonS. AliD. W. JohnsonC. HainesR. J. RosychukR. A. KeaschukP. JacobsM. Cappelli and T. P. Klassen, Who comes back? Characteristics and predictors of return to emergency department services for pediatric mental health care, Acad. Emerg. Med., 17 (2010), 177-186. doi: 10.1111/j.1553-2712.2009.00633.x.

[26]

Y. Y. Ng, Optimal use of emegency services, SFP, 40 (2014), supplement 8-13.

[27]

S. NunëzA. Hexdall and A. Aguirre-Jaime, Unscheduled returns to the emergency department: An outcome of medical errors?, Qual. Saf. Health Care., 15 (2006), 102-108.

[28]

K. O'LoughlinK. A. HackingN. SimmonsW. ChristianR. SyahaneeA. Shamekh and N. J. Prince, Paediatric unplanned reattendance rate: A&E clinical quality indicators, Arch. Dis. Child., 98 (2013), 211-213.

[29]

L. Pereira, C. Choquet and A. Perozziello et al, Unscheduled return visits after an emergency department (ED) attendance and clinical link between both visits in patients aged 75 years and over: a prospective observational study, PloS One, 10 (2015), e0123803. doi: 10.1371/journal.pone.0123803.

[30]

H. QiuX. ChenW. LiuG. ZhouY. Wang and J. Lai, A fast11-solver and its applications to robust face recognition, J. Ind. Manag. Optim., 8 (2012), 163-178.

[31]

J. RyanJ. Hendler and K. P. Bennett, Understanding emergency department 72-hour revisits among medicaid patients using electronic healthcare records, Big Data, 3 (2015), 238-248. doi: 10.1089/big.2015.0038.

[32]

Y. Saeys, I. Inza and P. Larrañaga, A review of feature selection techniques in bioinformatics, 23 (2007), 2507-2517. doi: 10.1093/bioinformatics/btm344.

[33]

G. SauvinY. FreundK. SaidiB. Riou and P. Hausfater, Unscheduled return visits to the emergency department: Consequences for triage, Acad. Emerg. Med., 20 (2013), 33-39. doi: 10.1111/acem.12052.

[34]

Y. SunB. H. HengS. Y. Tay and K. B. Tan, Unplanned 3-day re-attendance rate at Emergency Department and hospital's bed occupancy rate, Int. J. Emerg. Med., 8 (2015), 324-329. doi: 10.1186/s12245-015-0082-3.

[35]

C. R. Trivedy and M. W. Cooke, Unscheduled-return-visits (URV) in adults to the emergency department (ED): A rapid evidence assessment policy review, Emerg. Med. J., 32 (2015), 324-329. doi: 10.1136/emermed-2013-202719.

[36]

S. J. J. VerelstS. PierlootD. DesruellesJ.-B. Gillet and J. Bergs, Short-term unscheduled return visits of adult patients to the emergency department, J. Emerg. Med., 47 (2014), 131-199. doi: 10.1016/j.jemermed.2014.01.016.

[37]

A. K. C. WaiC. M. ChorA. T. C. LeeY. SittambunkaC. A. Graham and T. H. Rainer, Analysis of trends in emergency department attendances, hospital admissions and medical staffing in a Hong Kong university hospital: 5-year study, Int J. Emerg. Med., 2 (2009), 141-148. doi: 10.1007/s12245-009-0098-7.

[38]

Y. WangG. ZhouL. Caccetta and W. Liu, An alternative Lagrange-dual based algorithm for sparse signal reconstruction, IEEE Trans. Sig. Process., 59 (2011), 1895-1901. doi: 10.1109/TSP.2010.2103066.

[39]

C. Wei and X. Tang, A fuzzy group decision making approach based on entropy, similarity measure, Int. J. Inf. Technol. Decis. Mak., 10 (2011), 1111-1130. doi: 10.1142/S0219622011004737.

[40]

C. L. WuF. T. WangY. C. ChiangY. F. ChiuT. G. Lin and L. F. Fu et al, Unplanned emergency department revisits within 72 hours to a secondary teaching referral hospital in Taiwan, J. Emerg. Med., 38 (2010), 512-517. doi: 10.1016/j.jemermed.2008.03.039.

Table 1.  List of Potential Risk Factors
Index Factor Name
1 Age
2 Gender
3 Race
4 Registration day of week (DOW)
5 Registration public holiday and Sunday (HAS)
6 CC1 orthopaedic (ORTHO)
7 CC1 gastrointestinal (GI)
8 CC1 respiratory (RES)
9 CC1 general & minor
10 CC1 external causes of morbidity
11 CC1 neurologic
12 CC1 cardiovascular (CV)
13 CC1 skin
14 CC1 eye complaints (EC)
15 CC1 ear, neck, throat
16 CC1 substance misuse (SM)
17 CC1 others
18 EDTC2 category
19 Diagnosis: general symptoms (GM)
20 Diagnosis: acute respiratory infection (ARI)
21 Diagnosis: sprains and strains (SS)
22 Diagnosis: minor head injury (MHI)
23 Diagnosis: diseases of oesophagus, stomach, duodenum
24 Diagnosis: COPD3
25 Diagnosis: fracture upper limb (FUL)
26 Diagnosis: fracture lower limb (FLL)
27 Diagnosis: open wound upper limb (OWUL)
28 Diagnosis: superficial injuries (SIN)
29 Diagnosis: intestinal diseases (ID)
30 Diagnosis: rheumatism (RHE)
31 Diagnosis: diseases of ear and mastoid (DEM)
32 Diagnosis: open wound of head, neck, and trunk (OW of HNT)
33 Diagnosis: neurotic disorders (ND)
34 Diagnosis: viral diseases (VD)
35 Diagnosis: complications of care (COMC)
36 Diagnosis: open wound lower limb (OWLL)
37 Diagnosis: others in ICD-9-CM4 groups
38 PAC5 status
39 Social issues (SI)
40 National service full-time (NSTF)
41 Handover
42 Medical history diabetes
43 Medical history asthma
44 Medical history cardiovascular disease
45 Average temperature (ave temp.)
46 Average pulse
47 Diastolic blood pressure (DBP)
1 CC stands for chief complaint
2 EDTC stands for emergency diagnostic and therapeutic centre. Certain emergency patients are observed at EDTC for up to 24 hours before being admitted or discharged
3 COPD stands for chronic obstructive pulmonary disease
4 ICD-9-CM stands for international classification of diseases, 9th revision, clinical modification
5 PAC stands for patient acuity category
Index Factor Name
1 Age
2 Gender
3 Race
4 Registration day of week (DOW)
5 Registration public holiday and Sunday (HAS)
6 CC1 orthopaedic (ORTHO)
7 CC1 gastrointestinal (GI)
8 CC1 respiratory (RES)
9 CC1 general & minor
10 CC1 external causes of morbidity
11 CC1 neurologic
12 CC1 cardiovascular (CV)
13 CC1 skin
14 CC1 eye complaints (EC)
15 CC1 ear, neck, throat
16 CC1 substance misuse (SM)
17 CC1 others
18 EDTC2 category
19 Diagnosis: general symptoms (GM)
20 Diagnosis: acute respiratory infection (ARI)
21 Diagnosis: sprains and strains (SS)
22 Diagnosis: minor head injury (MHI)
23 Diagnosis: diseases of oesophagus, stomach, duodenum
24 Diagnosis: COPD3
25 Diagnosis: fracture upper limb (FUL)
26 Diagnosis: fracture lower limb (FLL)
27 Diagnosis: open wound upper limb (OWUL)
28 Diagnosis: superficial injuries (SIN)
29 Diagnosis: intestinal diseases (ID)
30 Diagnosis: rheumatism (RHE)
31 Diagnosis: diseases of ear and mastoid (DEM)
32 Diagnosis: open wound of head, neck, and trunk (OW of HNT)
33 Diagnosis: neurotic disorders (ND)
34 Diagnosis: viral diseases (VD)
35 Diagnosis: complications of care (COMC)
36 Diagnosis: open wound lower limb (OWLL)
37 Diagnosis: others in ICD-9-CM4 groups
38 PAC5 status
39 Social issues (SI)
40 National service full-time (NSTF)
41 Handover
42 Medical history diabetes
43 Medical history asthma
44 Medical history cardiovascular disease
45 Average temperature (ave temp.)
46 Average pulse
47 Diastolic blood pressure (DBP)
1 CC stands for chief complaint
2 EDTC stands for emergency diagnostic and therapeutic centre. Certain emergency patients are observed at EDTC for up to 24 hours before being admitted or discharged
3 COPD stands for chronic obstructive pulmonary disease
4 ICD-9-CM stands for international classification of diseases, 9th revision, clinical modification
5 PAC stands for patient acuity category
Table 2.  Top 15 Risk Factors Selected Using Filter Methods
JMI MIFS CMIM MRMR ICAP CIFE DISR CMI ConDred
SI SI SI SI SI SI SI SI SI
PAC PAC PAC PAC PAC PAC diag: COPD PAC PAC
DBP diag:ID DBP diag:ID DBP ave pulse CC stance ave SM DBP
ave pulse reg HAS ave pulse reg HAS ave pulse DBP diag:ND DBP EDTC
diag:COPD diag:COMC diag:COPD diag:OWLL diag:COPD age diag:OWLL reg DOW CC others
age diag:OWLL age diag:OW of HNT age reg DOW handover age diag:MHI
CC RES diag:OW of HNT handover diag:COMC gender race CC RES race age
gender diag:VD gender diag:ND handover diag:COPD diag:OWUL ave temp. NSFT
ave temp. diag:DEM ave temp. diag:DEM ave temp. ave temp. diag:FLL gender ave pulse
handover CC SM CC RES ave temp. CC GI gender diag:OW of HNT CC ORTHO CC ORTHO
race diag:RHE CC EC diag:FLL race CC RES PAC diag:GM diag:GM
EDTC diag:SIN CC ORTHO diag:RHE NSFT handover EDTC diag:others in ICD9 CC CV
NSFT diag:FLL race diag:OWUL reg DOW NSFT diag:DEM CC RES diag:ARI
CC ORTHO diag:FUL NSFT diag:SIN diag:ND diag:GM diag:ID CC GI CC RES
reg DOW diag:OWUL diag:ND gender diag:GM medical history asthma CC EC NSFT diag:SS
JMI MIFS CMIM MRMR ICAP CIFE DISR CMI ConDred
SI SI SI SI SI SI SI SI SI
PAC PAC PAC PAC PAC PAC diag: COPD PAC PAC
DBP diag:ID DBP diag:ID DBP ave pulse CC stance ave SM DBP
ave pulse reg HAS ave pulse reg HAS ave pulse DBP diag:ND DBP EDTC
diag:COPD diag:COMC diag:COPD diag:OWLL diag:COPD age diag:OWLL reg DOW CC others
age diag:OWLL age diag:OW of HNT age reg DOW handover age diag:MHI
CC RES diag:OW of HNT handover diag:COMC gender race CC RES race age
gender diag:VD gender diag:ND handover diag:COPD diag:OWUL ave temp. NSFT
ave temp. diag:DEM ave temp. diag:DEM ave temp. ave temp. diag:FLL gender ave pulse
handover CC SM CC RES ave temp. CC GI gender diag:OW of HNT CC ORTHO CC ORTHO
race diag:RHE CC EC diag:FLL race CC RES PAC diag:GM diag:GM
EDTC diag:SIN CC ORTHO diag:RHE NSFT handover EDTC diag:others in ICD9 CC CV
NSFT diag:FLL race diag:OWUL reg DOW NSFT diag:DEM CC RES diag:ARI
CC ORTHO diag:FUL NSFT diag:SIN diag:ND diag:GM diag:ID CC GI CC RES
reg DOW diag:OWUL diag:ND gender diag:GM medical history asthma CC EC NSFT diag:SS
Table 3.  Prediction Results Including Factor of Social Issues
Set of risk factors Training set Test set
sensitivity specificity overall sensitivity specificity overall
S0 29.4% 86.2% 83.5% 29.3% 85.8% 83.3%
Set of risk factors Training set Test set
sensitivity specificity overall sensitivity specificity overall
S0 29.4% 86.2% 83.5% 29.3% 85.8% 83.3%
Table 4.  Prediction Results Excluding Factor of Social Issues
Set of risk factors Training set Test set
sensitivity specificity overall sensitivity specificity overall
S1 41.1% 74.2% 72.5% 40.3% 74.1% 72.4%
S2 40.6% 74.5% 72.8% 40.1% 74.1% 72.6%
S3 40.6% 74.4% 72.7% 40.1% 74.2% 72.7%
S4 40.3% 74.4% 72.8% 39.9% 74.4% 72.8%
Set of risk factors Training set Test set
sensitivity specificity overall sensitivity specificity overall
S1 41.1% 74.2% 72.5% 40.3% 74.1% 72.4%
S2 40.6% 74.5% 72.8% 40.1% 74.1% 72.6%
S3 40.6% 74.4% 72.7% 40.1% 74.2% 72.7%
S4 40.3% 74.4% 72.8% 39.9% 74.4% 72.8%
Table 5.  Prediction Results Using Logistic Regression
Training set: 211,160 Test set: 117,573
Hosmer-Lemeshow test p < 0.001 p < 0.001
C-statistic of ROC curve 0.67 0.66
Predictive accuracy sensitivity specificity overall sensitivity specificity overall
70% cutoff 1.7% 99.9% 95.4% 1.0% 99.9% 95.5%
50% cutoff 4.6% 99.9% 95.5% 2.4% 99.9% 95.5%
20% cutoff 11.9% 99.3% 95.2% 7.2% 99.4% 95.2%
10% cutoff 18.5% 96.3% 92.7% 14.1% 96.1% 92.4%
5% cutoff 51.6% 72.2% 71.2% 51.0% 70.8% 69.9%
Training set: 211,160 Test set: 117,573
Hosmer-Lemeshow test p < 0.001 p < 0.001
C-statistic of ROC curve 0.67 0.66
Predictive accuracy sensitivity specificity overall sensitivity specificity overall
70% cutoff 1.7% 99.9% 95.4% 1.0% 99.9% 95.5%
50% cutoff 4.6% 99.9% 95.5% 2.4% 99.9% 95.5%
20% cutoff 11.9% 99.3% 95.2% 7.2% 99.4% 95.2%
10% cutoff 18.5% 96.3% 92.7% 14.1% 96.1% 92.4%
5% cutoff 51.6% 72.2% 71.2% 51.0% 70.8% 69.9%
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